Do you have the right genes for ozone therapy?
SOD – What does it mean and what does it do?
First, let’s get some of the abbreviations out of the way:
SOD stands for superoxide dismutase.
It is an enzyme which scavenges the free oxygen radical superoxide O2-. Without SOD, superoxide O2- would cause some serious damage to cells.
Consequently, it is assumed that an impaired SOD gene would lead to a lack of SOD enzymes and so to too many superoxide radicals and hence cause too much oxidation. An overactive SOD gene could lead to an overabundance of SOD enzymes and hence to less superoxide radicals and in turn to a better protection against oxidant radicals.
There are three different types of SOD enzymes: SOD1, SOD2, and SOD3.
Some colorful drawings to keep you from falling asleep: SOD1 is also called CuZnSOD, because it contains copper and zinc. It is mostly found inside cells. SOD2 is also called MnSOD, because it contains manganese, it is mostly found in the mitochondria. SOD3 is also called ECSOD because it is found in extracellular fluid. It also contains zinc and copper. Source: Wikipedia.
What does it mean to be homozygous or heterozygous for an SOD gene?
Your test shows alleles not mutations
“SOD1 polymorphisms, like many enzyme polymorphisms, can be either and [sic] up-regulation or a down-regulation of enzyme activity.”
The most important SOD2 variant
Let’s go back to the example.
Let’s pick what is often cited as the most important SOD2 SNP: rs4880.
Looking at the test above, all it tells us, is that the person has received the same variant from her mom as from her dad. For now, it is just raw data.
What we would like to know though, what consequence does this have for the ability to handle oxidative stress, correct?
In order to find out, we have to do what all the interpreters of those type of genetic tests do: consult www.snpedia.com. The site collects all the research on all the SNPs and makes it easy to look them up.
After typing in rs4880 this is what we get:
Here comes the shocker (or not if we remember what we found out above): that we do not know for sure whether having the rs4880 variant of the SOD2 gene means that you are producing more or less of this enzyme. Since there is a “conflict” in research. The science is not clear.
So following the logic of believers in SOD SNP, being homozygous for rs4880 could mean you are either overprotected against the damages of superoxide radicals or that you are underprotected and especially vulnerable.
The page then goes on to list a bunch of research papers on that variant with links to many diseases. Some of them quite scary sounding like heart disease and cancer.
Pay attention to one crucial word though: association. The listed research papers are all associations. Those are not cause and effect relationships. Meaning: science doesn’t really know what real life meaning those SNPs have for you or if any at all.
No actual double blind randomized studies have been performed to find out what rs4880 causes or not. What this “research” is based on is statistical acrobatics on a bunch of data, trying to find meaning in numbers. Evaluating risk, not real diseases.
So taking supplements to help with those type of genetic “defects” is equivalent to have one’s breasts amputated due to similarly imperfect research: it is an overreaction based on shoddy science.
Would you like to pick my brain about SOD and ozone? Book a Skype session with me! It'll be fun.
Ok, I’m German, so no guarantees about the fun part. But you could enjoy it anyway 🤓.
Should you do ozone therapy with SOD SNPs present?
Hence the lack of SOD which only neutralizes the superoxide radical is of no consequence for those who do ozone therapy.
2. Ozone is known to significantly increase SOD production.
Here a copy of the beginning of a 9 pages chapter from the book “Ozone Therapy. Oxidative Conditioning, Basis for its Clinical Effectiveness” dealing ONLY with how ozone therapy increases SOD activity.
It turns out, if you have low SOD levels, ozone therapy is likely the best thing you can do to increase them.
You like ozone therapy and get off on arcane statistical analyses? Then this is the book for you: it has everything to make the heart of a science geek jump with joy. Word puzzles made out of perplexing abbreviations, obscure biochemical, and medical terminology. Extra bonus for the linguistical fiend: it is written by non-native English speakers. The bottom line of all the linguistic tongue-twisters: ozone therapy is good and it increases SOD activity.
Other reasons why you should pay no attention to your SOD SNPs
– The science behind DNA interpretations is still very much in its infancy, rife with errors and inconsistencies. Here an example:
“Nowhere are the problems with statistics more blatant than in studies of genetic influences on disease. In 2007, for instance, researchers combing the medical literature found numerous studies linking a total of 85 genetic variants in 70 different genes to acute coronary syndrome, a cluster of heart problems. When the researchers compared genetic tests of 811 patients that had the syndrome with a group of 650 (matched for sex and age) that didn’t, only one of the suspect gene variants turned up substantially more often in those with the syndrome — a number to be expected by chance.
“Our null results provide no support for the hypothesis that any of the 85 genetic variants tested is a susceptibility factor” for the syndrome, the researchers reported in the Journal of the American Medical Association.”
Which are the right genes for ozone therapy?
If you belong to the species of homo sapiens, chances are good you have the right genes in order to do ozone therapy. As a matter of fact, if you are any type of mammal, you will likely benefit from ozone therapy.
Do you resemble any of the creatures in this photo? If so, then ozone therapy could be of benefit for you.
With one (theoretical) exception: it is assumed by many ozone experts that people with the G6PD deficiency should not do ozone therapy since the G6P enzyme is critical for how ozone therapy works. I quote this is a theoretical exception since I don’t know of any cases of people with this condition who had an adverse reaction to ozone therapy. As a matter of fact, Prof. Bocci cites a case in his book “Ozone, a New Medical Drug” of a woman with G6PD deficiency who benefited from ozone. Yet, at the same time he cautions against the use of ozone therapy with the G6PD condition.
If you satisfy the above mentioned criteria (positive for homo sapiens) and yet still do poorly on ozone therapy, the likely culprit are toxic metals, not genes. Contrary to the belief of many ozone practitioners, ozone will not chelate mercury and other metals.
Another culprit can be candida and yeast. Ozone can both help with yeast infections (the underlying cause of which is mostly mercury poisoning) but it can also make it worse. How is that? Under the right circumstances ozone can push your body into ketosis, and especially candida is able to not only survive on ketones but even go systemic.
More on that here.
“Many consumers who are determined to learn what their DNA holds are looking for some measurement of risk — diseases that they’re genetically predisposed to develop, or weaknesses that might inform proactive lifestyle changes. But assessing that risk completely would essentially require the interpretation of a language of which our current understanding is very incomplete. While services want people to [be] able to understand their genetic data, the reality is that science still understands very little of the language of the human genome.”
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