How to Do Nasal Insufflations with Ozone

by | Last updated: Jun 15, 2020 | 24 comments

During nasal ozone insufflations a mix of ozone and oxygen is introduced into the sinus area.

For this, a syringe, silicone covers, and a relatively low ozone concentration of 5 to 20 mcg/ml are used. 

Nasal insufflations with ozone can be easily done at home.

Introducing ozone into the sinus cavity can help with congestions, stuffy nose, upper respiratory infections, allergies, brain fog, and other brain related conditions.

What equipment do you need for nasal ozone insufflations?

You will need:

What equipment you need for nasal insufflations


  1. Oxygen source plus regulator, here it's an industrial oxygen tank and an industrial low flow regulator
  2. Ozone generator, here it's a Promolife Dual
  3. Accessories: ozone resistant syringe, silicone covers, luer lock connectors, silicone tubing (around 3 ft.)
  4. Syringe filling station

How to do nasal insufflations with ozone: step-by-step

Suggested settings

Ozone concentration: 5 to 20 mcg/ml
Oxygen flow: not important, since a syringe is used
Gas volume: 10 to 20 ml


Suggested settings

Ozone concentration:

5 to 20 mcg/ml

Oxygen flow:

not important with a syringe

Gas volume:

10 to 20 ml

  1. Screw the low flow regulator onto the oxygen tank.

2. Take a piece of tubing and connect one end to the regulator. 

3. Take a luer lock connector and push it into the other end of the silicone tubing. 

4. Screw the end with the luer lock onto the “oxygen in” port of the ozone generator.

5. Screw the syringe filling station onto the “ozone out” port of the ozone generator. 

6. Make sure the OFF knob on the filling station is turned towards the syringe port.

7. Plug the ozone generator into the power supply. 

8. Open the oxygen tank with half a turn on the valve. Watch the gauge jump up on the regulator.  

9. Pick the correct settings on your ozone generator. I chose an ozone concentration of 7 mcg/ml which means that I need to set the oxygen flow to 1/4 LPM and the first ozone output dial to 1. 

10. Set the oxygen flow on the regulator to 1/4 LPM. 

11. Screw the syringe onto the filling station. 

12. Set the first dial of the Promolife Dual Cell to one. The second dial remains in the OFF position. 

13. Turn the OFF knob on the filling station so that it points towards the destructor. Now ozone/oxygen gas is flowing into the syringe. 

14. Fill syringe until the 20 cc mark. 

15. Turn the OFF knob on the filling station towards the syringe. This stops the ozone/oxygen flow. 

16. Turn the ozone generator off. 

17. Turn the regulator to zero. 

18. Unscrew the syringe from the syringe filling station. Keep it upright.

19. Put the silicone cover on the syringe. 

20. Take a deep breath. 

21. Insert the syringe into a nostril. Keep the other nostril closed and inject the content of the syringe into your nose, all the time while holding your breath. 

22. Remove the syringe and keep your nose pinched. Keep holding your breath for another 10 seconds. 

23. Release the ozone from your nose and mouth by exhaling. Make sure to move away. Do not breathe it back in. 

24. Do the same with the other nostril by repeating steps 10 to 23. 

25. When you're done, close the valve of the tank. Don't exert too much force. 

26. Release the pressure in the regulator by opening it all the way, here it's 4 LPM. Wait until the gauge goes down to zero. It will take only a few seconds. Then set the regulator to zero again. 

What are nasal insufflations with ozone used for?

They are used to treat a variety of upper respiratory issues:

  • sinus infections
  • sinusitis
  • allergies
  • cold
  • runny nose
  • brain fog

They could potentially help with trigeminal neuralgia, eye problems, but also brain related issues. 

Risks and contraindications


  • accidentally breathing ozone in
  • irritation of the nasal mucosa and inflammation


  • transplanted organs, since ozone treatments can boost the immune system and trigger a rejection of the foreign organ
  • acute asthma attack

The Crazy Ozone Lady's take on nasal ozone insufflations

One of my first experiences with ozone were nasal irrigations with ozonated water. 

So, it was something close to nasal insufflations. 

I loved the irrigations: they were clearing up my mind, lifting my mood, and I was getting rid of the dandruff at the back of my head!

Just by sniffing ozonated water. Amazing!

Nasal insufflations on the other hand I found much harsher than the water, so I never used them as often as the nasal irrigations. 

For the purpose of making this guide, it was the first time in over 10 years that I attempted them again. And just like in the past, I found them to be painful and uncomfortable. My nose felt raw for a few days afterwards. 

So, I'm not a fan. It's possible that with a lower concentration the experience would have been more bearable. 

But if the need shall arise in the future to treat my sinuses, I'd rather do the irrigations. 

About the author:

PaolaI’m Paola the Crazy Old Ozone Lady behind The Power of Ozone. I’m a licensed naturopathic practitioner, natural health consultant, ozone therapy enthusiast, researcher, and ozone therapy analyst. I hold certificates in ozone therapy, hyperbaric ozone applications, Oxyvenierung, and the Andrew Cutler chelation. I own several ozone generators including a German hyperbaric 10 Pass machine. I have been using ozone for over 13 years, I’ve chelated with the ACC program for close to 5 years and I’ve been carnivore for nearly 1.5 years. This website serves as a resource for those who are interested in ozone therapy and other approaches to successfully manage chronic conditions.

Legal Disclaimer

Information provided is for informational purposes only and is not a substitute for professional medical advice. No health claims for these products or treatments have been evaluated by the United States Food and Drug Administration (FDA), nor has the FDA nor any other medical authority approved these treatments or products to diagnose, cure, or prevent disease. Neither The Power of Ozone nor the manufacturers of these items are responsible for the misuse of this equipment or the information on this page. It is highly advised to receive professional council from a licensed doctor before using ozone therapy or any of the mentioned products or tests on yourself.

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  1. Laney

    I agree with Paola! Nasal insufflation can be harsh.

    When I first tried the ozone gas nasal insufflation, it was amazing. At the beginning, I did follow the gas insufflation with ozonated water via a ceramic neti – the BEST!! The only way to describe it is as a nose-gasm and a pleasant “buzz” with a pleasant total body pop of energy following the neti rinse (I also noticed that if I did ozonated neti the day after a 10 pass, the orgasmic nasal “buzz” would last up to half an hour! Anyways…). A lot of dark yellow mucus came out the first week. As I continued to do this daily, I found that doing both became too harsh and unbearable. I continued the ozonated neti until the beginning of this year.

    Seems like my sinus issues are back (the pressure) but I just broke my water bubbler… I’m nervous about doing the insufflation and considering BOO but would like to do a nasal rinse with ozonated oil.

    How much ozonated oil should be added to the salinated rinse? I did see this info before somewhere in a comment but can’t find it.

    Any insights/comments are appreciated. Thank you!

  2. Alex

    Great info.

    Right now I feel disassociated and brain fogged from too much nasal ozone from syringe. Thoughts on how to reverse this? I did this once before and time helped , wondering if there's a quick way as I'm concerned for my brain cells and inability to think properly. Thank you

    • Paola Dziwetzki

      Hi Alex,

      I just sent you an email. Please, check your inbox. I would like to talk about this.


  3. Andrea

    How do I try nasal insufflations if I have an ozone generator that doesn’t have a regulator?

    • Paola Dziwetzki

      Hi Andrea,

      I am not quite sure I understand what you mean … since most personal ozone generators don't have a regulator.

      Or do you mean a dial knob? So, you have an ozone generator with just an on/off switch, is that it?

      If that's the case, just use a high flow setting to fill the syringe. But be careful, because it will go very fast.


  4. Meg Schlachter

    Hi Paola, I did not notice any instructions on your website about nasal irrigations. Is it just as simple as using a net pot with cold ozonated water? Thanks for everything you do.

  5. Terri Denman

    What us the dosage for nasal ozone?

    • Paola Dziwetzki

      Hi Terri,

      it's a volume of 10 to 20 ml at an ozone concentration of 5 to 20 mcg/ml.


  6. John

    Thanks a lot for that Paola.. If one wanted to do a sauna and use the same time to breathe oil bubbler ozone, does that mean, not just 2 generators but also two o2 bottles, 2 regulators?

    • Paola Dziwetzki

      Hi John,

      yes, you'd need two of each.


    • Student of Life

      Hi John,

      Peroxide can be cold mist nebulized, after being diluted to around 1% w distilled water. Many claim they’ve eliminated chronic COPD & all kinds of other serious lung issues w this method & I know those who use it highly successfully for acute illnesses. One of the best treatments for “flu like illnesses” along w oral doses of food grade peroxide, per those that don’t have ozone set ups.

      From my understanding it’s the closest thing too BOO, wo requiring the fairly expensive setup, & only costs about $35 to buy everything. Hopefully Paula can add some of her snarky wisdom & experience w this alternative form of oxidative medicine

      Hope this helps.

    • Paola Dziwetzki

      Hi Student of Life,

      Yes, nebulized peroxide is a great alternative to BOOO, I agree.
      People use anything from 0.5 to 3%, or even less than 0.5%.


  7. John

    Hello Paola, Thank you for the info. above, if we followed your nasal ozonated water instead of insufflations, what concentration should the water be?

    • Paola Dziwetzki

      Hi John,

      I would ozonate the water at 30 to 40 mcg/ml.


  8. Maria Torres

    Hello, thank you for the great instructions. We did one last night and I put the settings very low since the first time we did it too strong and hurt us.

    With the low settings my kids didn’t complain and it’s helping them get over strep. How often do you recommend we do this? Would daily be too much?

    • Paola Dziwetzki

      Hi Maria,

      this can be done every day multiple times a day as long as the NI won't cause too much irritation and are not too harsh.

      Better approach in my opinion are nasal irrigations with ozonated water or ihalations with peroxide.


  9. Linda Saloman

    Hi! Paola, I need your help,
    I would like to try the nasal insufflation as well as the ear insufflation. Question; When you inhale or push the ozone from the syringe, do you squirt the ozone all at once? Also my ozone generator is not like yours so, how would I know what is the lowest LPM that I should set the ozone generator. This is my ozone generator chart without dial.
    Oxygen Flow:LPM Ozone Concentration: UG/ ML
    1/32. 99

    1/16. 85
    1/8. 70
    1/4. 40
    1/2. 20
    3/4. 12
    1. 5
    Your help will be appreciated ; Yours,

    • Paola Dziwetzki

      Hi Linda,

      Yes, you squirt the ozone pretty much in one go. You need to move quickly since most people can't hold their breath for a long time.

      I would use 3/4 LPM or 1/2 LPM on your generator. Or 1/4 but turn the generator on only for 1/3 of the syringe and fill the rest with just pure oxygen to dilute the ozone.

      I recommend lower ozone concentrations for NI since they can be very intense.


  10. Justine Laidlaw

    OMG just did my first one now, my nostrill's are throbbing now, hopefully that means a good thing! How many treatments are people usually doing per/day/week to get the results of improvement, any ideas?

    • Paola Dziwetzki

      Hi Justine,

      yes, they can be quite uncomfortable, which is why I'm not a big fan.

      Try to reduce the concentration and see if this is better.

      Best is to use ozonated water irrigations in my opinion.

      As to how often to use: depends on what you're treating and if it's helping you.

      In general, you can do them daily. Unless your nostrils are too raw from the last treatment. Then wait it out first and switch to EI, ear insufflations or drinking ozonated water.


    • Justine Laidlaw

      Thanks Paola your a star x

    • Paola Dziwetzki

      Thank you!

  11. Graham

    Love that, even a dummie like me can't go wrong, just need to get a filling station now.
    How long did you take to get pic 23 just right, looks like you are blowing us all a kiss!!!

    • Paola Dziwetzki

      Hi Graham,

      glad you like it.

      That one didn't take that long, but had to reshoot #20 forever LOL.


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