[updated January 2019]
One of the many great things about doing ozone at home is that after just a short amount of time you'll be able to revise many things you've been told by your doctor or any other “expert” and become your own ozone expert.
Over the past 7 years I have met 5 ozone doctors personally, and have studied the teachings of a former Canadian ozone practitioner who used to run a Yahoo group. I find that of all the ozone doctors I talked to he is the one who understood ozone the best, although he seemed to have the least academic credentials. He was able to explain best what was happening to me and predict what would happen with continued ozone applications. I also found out that he was wrong about a number of things. So overall, all the ozone doctors I've consulted or talked to over the years contradicted each other to one degree or another. Then there is literature which again says something else and many websites which give yet another side of the story. So the confusion is perfect. And the only way to cut through the crap is to try it out yourself and find out what's what. That's what I did. That's how I was able to bust many of the ozone myths in circulation, many of them very tenacious, nevertheless I found them to be often very wrong. And some to be true …  
Myth#1 “You need to humidify ozone before you do insufflations”
Different ozone experts give various reasons why one should humidify ozone before the various insufflations. I found out, either through logic, common sense or by experience or a combination of the above, why this is in most cases, wrong:  
1) “One needs to humidify ozone so the ozone can kill bacteria, viruses etc.”
Basically the ideas is that unless you humidify the o3 it won't be therapeutical. That ozone needs to be “activated” with water in order to work its magic.
Which obviously cannot be correct.
It's the ozone alone which has the potential to react and bond with other molecues. One can find many chemical equations on the internet which explain how ozone reacts with other substances. One such reaction is called “ozonolysis”. Here an example:

ozonolysis of alkenes

Source https://en.wikipedia.org/wiki/Ozonolysis

Nitrogen oxide can react with ozone without the additon of any water:

nitric oxide and ozone  

Source: http://scifun.chem.wisc.edu/chemweek/ozone/ozone.html

As can nitrogen alone: “The reaction of ozonized oxygen and active nitrogen at room temperature has been shown to produce, almost exclusively, nitrous oxide.”


Here many more reactions of ozone with substances like carbon, sulfur, or metals, all without the use of water: https://en.wikipedia.org/wiki/Ozon

ozonolysis of alkenes

If you've used ozone therapeutically on yourself, chances are good you have accidentally managed to bleach some towels or other fabric without using any water to achieve that. The oxidization of pigments which causes the fabric to bleach, that's more or less what ozone does to germs when it kills them – without the need of H2O.  
2) “You need to humidify ozone to make sure the ozone penetrates the inside of your body cavities – ear, vagina, rectum.”
This one is pretty easy to correct, as anyone can find out with the use of a few digits: all those cavities are already naturally “humidified” and hence penetrable to ozone or other substances.
With vagina and rectum it's pretty clear I'd say, although everyone is free to perform a digital test on oneself to verify that ;-).
Same about the ears – they feel wet inside.  But it's not water wetness, it's the waxy/oily substance that the ears naturally produce.
Ozone is lipophilic (loves oil) so it will be attracted to that oil and penetrate it and the underlying skin and if done long enough, the entire brain (*).
Nothing proved to be more soothing to my lyme infested [update December 2015: most likeley not lyme but inflammation caused by mercury], anxiety ridden, fogged up brain than some ear insufflations, performed without water.  
3) “You need to humidify the skin to make it penetrable”.
Humidification of the skin helps to make it more penetrable but more crucial is heat to create what Velio Bocci calls “skin vasodilatation” to widen the capillaries of the skin so that ROS (reactive oxygen species) and LPS (lipid oxidation products) can enter.
Some people use FIR (far infrared) saunas with ozone.
FIR saunas do not use any steam, so there is no water involved, and yet you can get all the benefits from o3 because the FIR sauna is able to open up your pores and make blood vessels more accessible for the ozone via dry heat.  
4) “You need to humidify ozone to prevent dryness”. In some instances prolonged ozone insufflations, either vaginal or aural, can create dryness. In the case of vaginal dryness due to the insufflations, humidification of ozone can remedy the situation. But some women also report increased vaginal liquid discharge after ozone insufflations. So one needs to look on a case by case basis.
With ear insufflations: as soon as dryness and crusting sets in, adding water to the process can make the situation much worse and painful. A suggested idea is to run the ozone through olive oil before doing ear insufflations. It seems that when it comes to skin, oil restores moisture, water tends to dry it out. That's why most people use a moisturizer after stepping out of the shower or after spending time in the swimming pool. If one has dry skin on hands in winter, one usually applies oil based skin products to restore moisture, instead of holding the hands under tap water.
So, in that vein: let's all enjoy some non-humidified insufflations 🙂


(*) many people experience an extreme dryness around their ears and a caking of the liquid which will come out of their ears as part of the detox process. This is an oil dryness and not water dryness, which could be alleviated by taking krill or flax oil.
(All ozone therapy recommendations are not mine – I'm not a doctor, I don't give medical advise.)