Drugs deplete vitamin A from the liver
The administration of drugs leads to the depletion of vitamin A from the liver.
This requires oxygen and NADPH. Both are either supplied or produced during ozone therapy.
The mobilized vitamin A then could account for the adverse reactions reported by those who have been doing ozone therapy while supplementing with vitamin A: https://thepowerofozone.com/ozone-therapy-vitamin-a-bad-combination/
"This study revealed for the first time that rat liver microsomes can metabolize retinol to polar products in a system which requires 02 and NADPH."
"It has also been shown before that administered retinol or retinoic acid are converted to oxidized and/or conjugated metabolites which are rapidly excreted into the bile (20, 21, 24). The degradative pathway described in this paper may provide an explanation for the mechanism involved in the production of some of these metabolites, and for the depletion of hepatic vitamin A after the administration of drugs (1) and various xenobiotics (4) which are known to interact with liver microsomes."
New Pathway for Retinol Metabolism in Liver Microsomes*
https://www.jbc.org/article/S0021-9258(18)89008-1/pdf