How to Do Subcutaneous Ozone Knee Injections
Subcutaneous ozone knee injections are a simple and effective treatment for joint pain.
In the case of inflammation or any type of damage to the soft tissue of the knee area, ozone injections can offer an immediate and substantial relief.
Subcutaneous knee injections are different from true joint or intra-articular injections (named “prolozone” injections by Dr. Frank Shallenberger) in that they are shallower and less ozone is used.
The needle used in subcutaneous ozone injections is smaller and shorter than what is used for true intra-articular injections.
For that reason they do not require anesthetics, are simpler to perform, and carry less risk than prolozone treatments.
- oxygen tank and regulator
- tank wrench
- ozone generator
- ozone syringe
- syringe filling station with a filter
- 30g 13 mm needle
- alcohol wipes
- cotton pad
- sharps bin
Scroll down to learn where you can order the recommended equipment and supplies.
|Ozone concentration:||10 to 30 mcg/ml|
|Oxygen flow:||not important with a syringe, depends on ozone generator|
|Gas volume:||2 to 5 ml per puncture site, 5 to 10 ml per knee|
10 to 30 mcg/ml
not important with a syringe, depends on ozone generator
2 to 5 ml per puncture site, 5 to 10 ml per knee
1. Screw the low flow regulator onto the oxygen tank.
2. Take a piece of silicone tubing, and connect one end to the oxygen tank.
3. Take the other end of the silicone tubing and a luer lock connector and push one into the other.
4. Screw the silicone tubing with the luer lock into the “oxygen in” port of the ozone generator.
5. Screw the syringe filling station onto the ozone outlet of the ozone generator. Make sure the OFF valve is turned towards the destructor.
6. Plug the ozone generator into the power supply.
7. Open the valve of the oxygen tank, just half a turn. Watch the regulator and see how the gauge jumps up. It shows you how much oxygen is left in the tank.
8. Open the regulator to 1/2 LPM.
9. Flush the lines: Count to 15 to let pure oxygen flow through the lines, the syringe filling station, and the filter.
10. Flush the syringe: screw it onto the syringe port of the syringe filling station and fill with pure oxygen.
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11. Unscrew and empty it.
12. Close the valve of the syringe filling station.
13. Screw the syringe onto the syringe port of the syringe filling station.
14. Check your ozone output chart and see which settings you will need. Choose an ozone concentration between 10 and 30 mcg/ml. I pick 15 mcg/ml. Which means I will need to keep the oxygen flow at 1/2 LPM and the first ozone dial on 5, the second remains off.
15. Set the dial on your ozone generator to the desired setting. In my example I set the first dial on 5, the second dial remains off.
16. Turn the lever on the syringe filling station to open the syringe port.
17. Fill the syringe with around 20 cc of ozone/oxygen mix if you will inject one knee.
18. Close the lever on the syringe filling station when the syringe is 20 cc full.
19. Turn the ozone generator off.
20. Close the regulator by setting it to zero.
21. Unscrew the syringe. Keep it upright.
22. Unpack the needle.
23. Screw the needle onto the syringe.
24. Set is aside for a moment.
25. Put gloves on
26. Sit in a position so that your knees are at a 90 degrees angle.
27. Locate the spots where you will inject the ozone, see the two pink circles in the picture. You can inject each knee on both sides of the patella. The injection spots are located left and right underneath the patella, in between the femur and the tibia. When you palpate them, you will feel two soft dimples.
28. Disinfect the injection site with an alcohol wipe.
29. Remove the cap from the needle. Flush it with ozone by pressing out a few ml.
30. Inject straight into one of the soft spots.
31. Press in a few ml of ozone/oxygen gas mix. You may feel a sensation of pressure.
32. Pull the needle out. Press a cotton pad on the puncture wound to stop the bleeding.
33. Repeat steps 30 to 32 on the other side of the same knee, and if necessary also on the other knee.
34. Put bandaids on.
35. Dispose of the needle in the sharps bin.
36. When you’re done with ozone for the day, make sure to release the pressure from the regulator. First, close the valve on the oxygen tank. Do not exert too much force but make sure you close it tightly.
37. Open the regulator all the way to the maximum flow. Watch the gauge on the regulator go down to zero within seconds.
38. Once the gauge is at zero, set the regulator to zero. You’re done!
This is the equipment I used in the pictures above:
- Medical oxygen: get a filled medical oxygen tank here. (Learn about other options here.)
- Low flow regulator, CGA870
- Ozone generator: Promolife Dual Cell (Read the product review)
- Wrench for the oxygen tank
- Syringe filling station
- Silicone tubing
- Needle: 30g, 13mm long
- Alcohol wipes
- Cotton pads
If you decide to buy from Promolife, use the following discount code to get 7% on ozone gear: TPO7D.
I am a great fan of subcutaneous ozone injections into the knees and other joints.
They are simple and easy to perform, are low risk, and can significantly reduce joint pain.
They are not as effective as true intra-articular joint injections.
Therefore, in order to achieve the same effect, multiple subcutaneous injections may be required.
The advantage of shallow ozone knee injections is that they do not call for an anesthetic, they are easy to learn, and they can be repeated as often as the need arises.
I’ve applied them on myself and many times on my Dad.
Want me to show you how it’s done? Then click on the magic button below.
Information provided is for informational purposes only and is not a substitute for professional medical advice. No health claims for these products or treatments have been evaluated by the United States Food and Drug Administration (FDA), nor has the FDA nor any other medical authority approved these treatments or products to diagnose, cure, or prevent disease. Neither The Power of Ozone nor the manufacturers of these items are responsible for the misuse of this equipment or the information on this page. It is highly advised to receive professional council from a licensed doctor before using ozone therapy or any of the mentioned products or tests on yourself.
About the author:
I’m Paola the Crazy Old Ozone Lady behind The Power of Ozone. I’m a licensed naturopathic practitioner, natural health consultant, ozone therapy enthusiast, researcher, and ozone therapy analyst. I hold certificates in ozone therapy, hyperbaric ozone applications, Oxyvenierung, and the Andrew Cutler chelation. I own several ozone generators including a German hyperbaric 10 Pass machine. I have been using ozone for over 13 years, I’ve chelated with the ACC program for close to 5 years and I’ve been carnivore for nearly 1.5 years. This website serves as a resource for those who are interested in ozone therapy and other approaches to successfully manage chronic conditions.