Ozone Therapy at Home – Settings for the 5 Most Popular Treatments

by | Last updated: Oct 20, 2020 | 4 comments

ozone settings for 5 most common ozone treatments

If you're doing ozone therapy at home you want to use the correct settings to prevent complications and at the same time to maximize get the most out of the treatments.

Taking these two factors into account, below you can find the recommended ozone settings for the following five most popular home ozone therapy treatments: 

  1. Rectal insufflations
  2. Vaginal insufflations
  3. Ear insufflations
  4. Ozonated water
  5. Ozone sauna

For each ozone treatment, you will find  the suggested ozone concentration, oxygen flow, ozone volume, and duration of the treatment.

Keep in mind that when it comes to ozone therapy there is an ongoing discussion among experts about how to best utilize the gas. There are only very few universally agreed upon best ozone practices.

Consequently, the presented recommendations are not incontestable, but rather serve as general guidelines. The ultimate measure is each patient's unique situation and response. 

What you read here may vary from my earlier suggestions you can find on my website since I adjusted some of the recommendations based on feedback from ozone users.

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General recommendations

General rule: start low & slow

Maximum ozone concentrations: 70 – 80 mcg/ml

Average ozone concentration: 40 – 60 mcg/ml

Therapeutic effect: at least 3x / week

Acute conditions: at least 1x / day

Rectal & ear insufflations: best via bag/syringe

Vaginal insufflation: best directly

mcg/ml = “gamma” = unit for ozone concentration

Adjust settings according to patient response

Ozone therapy is generally defined as the application of ozone at a concentration of not more than 70 – 80 mcg/ml.

A good average ozone concentration range for most home ozone treatments is 40 to 60 mcg/ml.

Exceptions to this are topical administrations, drinking of ozonated water, or treating active bleeding in ulcerative colitis. In some of these cases, the recommended ozone concentration can be as high as 100 mcg/ml.

It is often recommended to start with low ozone concentrations and volumes and to build up over several weeks. This allows the user to gradually tune into the body's response and to soften Herxheimer reactions.  

Generally, in order to reach optimal therapeutical outcomes ozone should be applied at least 3 times a week. Acute or more serious conditions may require daily or multiple times a day treatments.

The ozone concentration is given in mcg/ml (micrograms per milliliter), which is colloquially called “gamma”.

Indirect administrations (via a bag or syringe) allow for a more careful and measured approach and are recommended during rectal and ear insufflations. Since vaginal insufflations are low risk and don’t carry the possibility of rupturing anything, the direct method is preferable in this case.

indirect EI 2 copy

An example of indirect ear insufflations performed with the help of a 200 ml syringe.

Direct versus indirect ozone administration – What does it mean?

All insufflations can be performed directly or indirectly.

Indirectly means with the help of a bag or syringe which is filled first and then the content of the bag is emptied into the desired body cavity. Performing insufflations directly means that there is a direct, ongoing connection between the ozone generator and the human body through a catheter, tubing, or an earscope.

During the indirect method, the selected oxygen flow is irrelevant since the human body is never directly exposed to its effects.

During the direct method, on the other hand, the oxygen flow is very important. Here, a too high flow can result in the rupture of the ear drum, the colon, or a drying out of the vaginal cavity.

Typically used oxygen flows for the direct administration of ozone are 1/32, 1/16, or 1/8 LPM.

Users of SimplyO3 regulators have the option of additional low flows, including 12/32, 7/32, 6/32, 5/32, and 3/32 LPM.

rectal insufflation copy

A popular way to perform rectal insufflations is by using a bag, which is an indirect ozone administration.

1. Settings for rectal ozone insufflations

Indirect rectal insufflations (bag/syringe):

Ozone concentration: 20 to 60 mcg/ml

Oxygen flow: any you like

O2/O3 volume: 100 to 300 ml

Time: 30 sec for every 100 ml

Direct rectal insufflations:

Ozone concentration: 20 to 60 mcg/ml

Oxygen flow: 1/32 to 1/8 LPM

O2/O3 volume: 100 to 300 ml

Time: You need to calculate it by using the following formula: volume [L] / flow [LPM] = time [min]

Rectal insufflations can be performed directly or indirectly. Serious complications with rectal ozone administrations are extremely rare and can be easily prevented by choosing the indirect approach via a bag or syringe and a slow infusion of around 100 ml per 30 seconds.

A common volume to start with are 100 ml which can be increased over a few weeks to 300 ml. Many users take advantage of the entire volume of the bag and go as high as 750 ml.

A good average ozone concentration for rectal insufflations is 40 to 50 mcg/ml which can be used from the beginning without the need to build up to it.

The direct method requires a bit of mathematics: infusing too much gas too quickly could stress the intestinal walls in people with certain preconditions and lead to a rupture of the colon. To prevent this, low oxygen flows are used of not more than 1/8 LPM and the duration of the insufflation needs to be timed to not exceed the recommended volumes.


Pick how much gas you want to use: 100 ml = 0.100 liters

Select the oxygen flow: 1/16 LPM

What is the resulting duration for the insufflation?

Use formula: volume / flow = time

0.100 L / (1/16 LPM) = 1.67 min = 1 minute and 40 seconds

Exceptions for rectal insufflations:

Active bleeding during ulcerative colitis: here concentrations of up to 100 mcg/ml can be used.

As part of his high dose ozone program, Dr. Lahodny regularly uses volumes of 2,000 ml at an ozone concentration of 80 mcg/ml at increments of 10 ml. 

Click here for step-by-step instructions on how to do rectal ozone insufflations.

vaginal insufflations copy

Vaginal insufflations are best performed in a direct, continuous way. 

2. Settings for vaginal ozone insufflations

Direct vaginal insufflations:

Ozone concentration: 20 to 60 mcg/ml

Oxygen flow: 1/32 to 1/8 LPM

O2/O3 volume: 150 – 3,750 ml

Time: 5 to 30 min

Indirect vaginal insufflations (bag/syringe):

Ozone concentration: 20 to 60 mcg/ml

Oxygen flow: any you like

O2/O3 volume: at least 150 ml

Time: around 30 sec per 100 ml

Vaginal insufflations are one of the simplest and safest ozone treatments. They can also be performed directly and indirectly, but the most common method is the direct route by simply letting the gas flow in continuously.

With vaginal insufflations there is no risk of rupture, since all the excess gas can easily escape the way it came in.

An oxygen flow of 1/32, 1/16, or1/8 LPM can be selected. The lower the flow, the less drying is the effect and can even stimulate natural secretions.

A good way to begin vaginal insufflations is with 5 minutes per day at an ozone concentration of 20 to 30 mcg/ml and then to increase slowly to maximum 30 minutes per day at a maximum ozone concentration of 60 mcg/ml.

Should you choose the indirect route, a good speed of administration is around 100 ml per 30 seconds.

Click here for step-by-step instructions on how to do vaginal ozone insufflations.

indirect EI copy

In my opinion the indirect ozone administration during ear insufflations is the safest option.

3. Settings for ear ozone insufflations

Indirect ear insufflations (bag/syringe):

Ozone concentration: 5 to 60 mcg/ml

Oxygen flow: any you like

O2/O3 volume: at least 30 ml

Speed of administration: around 1 ml  / sec

Direct ear insufflations:

Ozone concentration: 5 to 60 mcg/ml

Oxygen flow: 1/32 to 1/8 LPM

O2/O3 volume: 30 – 2,500 ml

Time: less than 1 minute to 20 minutes

Ear insufflations can be performed both directly and indirectly. There are some risks involved with ear insufflations including excruciating pain, rupture of the ear drum, itching, tinnitus, and liquid discharge. Most people develop at least one of the listed side effects.

In order to minimize them, it’s of utmost importance to start with a low ozone concentration of 5 to 10 mcg/ml and a low gas volume of 30 to 60 ml best by using a syringe.

If there are no extreme reactions and no pain after doing this for several weeks at a frequency of not more than 3 times a week, then the ozone concentration and amount can be slowly increased.

The same careful approach should be used for the direct method. Here, I recommend to not apply ozone into the ears for longer than a minute in the beginning.

Click here for step-by-step instructions on how to do ear ozone insufflations.

ozonated water copy

A water bubbler with an attached destructor allows for the safe ozonation of water in closed spaces.

4. Settings for ozonated water

Ozonated water:

Ozone concentration: 40 to 100 mcg/ml

Oxygen flow: 1/8 to 1/4 LPM

O2/O3 volume: around 600 to 4,000 ml

Type of water: distilled & cold 

Time: from 5 to 15 minutes

Ozonating water is best performed with a water bubbler equipped with a destructor which prohibits the possibility of excess ozone in the room. Alternatively, any type of glass container like a glass jug or a washed out wine bottle can be used.

How long water needs to be ozonated depends on its mineral content, the pH, the temperature, the amount of water, and the ozone concentration.

Slightly acidic (below a pH of 7), mineral poor, cold water can absorb more ozone and can retain it for a longer time than warm water with a higher pH and a high mineral content.

The higher the ozone concentration, the less time is required to ozonate the water. At 100 mcg/ml 5 minutes are sufficient for 7 to 17 oz. (200 to 500 ml). The more water is used, the longer it will take to saturate it with ozone.

Rough guidelines:

1 to 2 glasses (@ 8 / 10 oz, or 200 to 250 ml, each): 5 to 10 minutes

3 to 4 glasses (@ 8 / 10 oz, or 200 to 250 ml, each): 10 to 15 minutes

Click here to learn more about ozonating water.

home ozone sauna setup example

An ozone sauna set-up with an oxygen concentrator. Ozone saunas are powerful systemic, non-invasive ozone treatments. 

5. Settings for ozone sauna

Ozone sauna:

Ozone concentration: 10 to 30 mcg/ml

Oxygen flow: 1/4 to 1/2 LPM

O2/O3 volume: around 2,500 to 15,000 ml

Temperature: enough for the skin to be moist and warm

Time: from 10 to 30 minutes

Of all the home treatments, ozone saunas require the highest oxygen flow, namely 1/2 LPM, to make up for the increased destruction of ozone through heat. 

Although topical applications can be performed with very high ozone concentrations, it is nevertheless recommended to keep it at 10 to 30 mcg/ml for ozone saunas to prevent the appearance of an often excruciatingly itchy rash.

The ideal duration for hyperthermic treatments are 30 minutes, but even 10 minutes can have an advantageous effect.

There is no specific temperature needed for the ozone sauna to be beneficial. As long as the skin is warm and moist, the ozone and its by-products can penetrate the skin and do their magic.

For this, sweating it not necessary at all, although it is likely an added perk.

Click here to learn more about ozone saunas.

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Learn more


Frank Shallenberger: “The Ozone Miracle

Renate Viebahn-Hänsler, Olga Sonia Leon Fernandez: “Ozone in Medicine, From Science to Guidelines and Treatment Concepts”, 2020

Renate Viebahn-Hänsler: “Ozon-Sauerstoff-Therapie”,2009

Roland Dehmlow, Marie-Theres Jungmann: “Handbuch der Ozon-Sauerstoff-Therapien”, 2000

Facebook: “The Ozone Group”


The Power of Ozone SHOP

About the author:

PaolaI’m Paola the Crazy Old Ozone Lady behind The Power of Ozone. I’m a licensed naturopathic practitioner, natural health consultant, ozone therapy enthusiast, researcher, and ozone therapy analyst. I hold certificates in ozone therapy, hyperbaric ozone applications, Oxyvenierung, and the Andrew Cutler chelation. I own several ozone generators including a German hyperbaric 10 Pass machine. I have been using ozone for over 13 years, I’ve chelated with the ACC program for close to 5 years and I’ve been carnivore for nearly 1.5 years. This website serves as a resource for those who are interested in ozone therapy and other approaches to successfully manage chronic conditions.

Legal Disclaimer

Information provided is for informational purposes only and is not a substitute for professional medical advice. No health claims for these products or treatments have been evaluated by the United States Food and Drug Administration (FDA), nor has the FDA nor any other medical authority approved these treatments or products to diagnose, cure, or prevent disease. Neither The Power of Ozone nor the manufacturers of these items are responsible for the misuse of this equipment or the information on this page. It is highly advised to receive professional council from a licensed doctor before using ozone therapy or any of the mentioned products or tests on yourself.

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This website contains links to vendors of products I endorse, including amazon.com. If you decide to make a purchase through one of my links, they will pay me a commission. This does not influence my opinion about the products, as you can see from my reviews.

Do you want answers? Great! I got answers. Loads of answers. But before you ask your question, contribute to my “Make Paola Bionic” project first, then come back here and I'll get you all the answers you want.


  1. Catharine

    Hi, I am a newby but very keen about ozone therapy. I have a small ozone generator that puts out 600mg/ hr. I use it to ozone my water and was wondering if this could also be use safely for vaginal insufflations and if so for what amount of time per session. I have an anterior prolapse and my urinary track is sloppy, do you thing ozone can strengthen the tissues and fix the problem allowing me to forgo surgery? Also, I had an accident in 08 that cause severe whip lash and brain shake leaving me with chronic air pockets throughout my brain. I am now experiencing some concerning symptoms. I know there is no medical treatment for this but wondering if ear insufflations sending ozone directly to my brain could maybe help me keep my mind intact and functioning as it should. Any answers or help you can offer would be amazing, thank you, Catharine

    • Paola Dziwetzki

      Hi Catherine,

      I do not recommend using the machine you have for any personal ozone treatments. What you have is most likely an air fed generator.

      What you need is an oxygen fed machine. This guide could help you pick out the right machine for you: https://thepowerofozone.com///wp-content/uploads/2020/10/the-ultimate-guide-to-buying-ozone-generator-2nd-edition-1.pdf

      For the prolapse – I'm not sure ozone would help. You could certainly try it out though. If there is some inflammation present in the tissue, then ozone could help. Otherwise, not sure.

      For the brain injury I would probably rather recommend hyperbaric oxygen therapy.

      Ear insufflations could possibly improve cognitive function. You'd have to try it out as well.


    • Donna

      Can you nebulizer h2o2? Would this be the same .

    • Paola Dziwetzki

      Hi Donna,

      yes, you can nebulize H2O2.


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This website contains links to vendors of products I endorse, including amazon.com. If you decide to make a purchase through one of my links, they will pay me a commission. This does not influence my opinion about the products, as you can see from my reviews.