Are Rectal Insufflations 95% as Effective as Intravenous Ozone?

by | Last updated: Feb 21, 2019 | 23 comments

The pictures shows Renate Viebahn (right) and me during a workshop in Germany in, I believe, summer of 2016, where Mrs. Viebahn was doing a presentation about ozone therapy. Mrs. Viebahn is not a medical doctor. Her background is, as she told me, chemistry. 


I don’t know how many times I have heard this phrase: “Rectal insufflations are 95% as effective as ozone IV” or “My doctor told me that rectal ozone is as good as the intravenous route” or some form of it.

The idea seems appealing: imagine not having to go to the doctor every time you need your ozone fix but instead being able to treat yourself in the comfort of your home. The treatment seems easy enough and requires only a few simple accessories. 

Problem is that having done both treatments, rectal and IV ozone, extensively on myself I’ve always been very skeptical about this claim.

Ozone IVs would often give me an immediate sensation of calm well-being, boost my energy, resolve joint pain, put me in a good mood. All things which I would not see after RI or only to a much smaller degree. I’ve also never seen a study which would have demonstrated that that often heard claim was true. 

And yet this idea keeps getting repeated over and over again. Many ozone doctors seem to have accepted it as fact and pass it on to their patients.

So, finally I wanted to find out where this notion comes from and how much truth there is behind it.

Here is what I’ve found:

Renate Viebahn – a German Ozone Expert

When researching the claim that rectal insufflations are supposed to be 95% as effective as intravenous ozone, one name keeps popping up repeatedly: Renate Viebahn.

She is the author of a number of books about ozone. Many of them don’t seem to be available anymore.

I own “Ozon-Sauerstoff-Therapie. Ein praktisches Handbuch” (“Ozone-oxygen therapy, a practical handbook”) from 2008.

There, Mrs. Viebahn writes the following on the topic of rectal insufflations (translated from German):

“… one can apply the following empirical formula: approximately triple the total ozone dosage per treatment for the rectal insufflation, that means, 3,000 mcg per treatment equate to 1,000 mcg ozone in the case of the Major Autohemotherapy”.

So she says that in order to get the same effect as one Major Autohemotherapy, one would have to use three times the dosage with rectal insufflations.

Meaning that one rectal insufflation is equivalent to around 1/3rd or around 30% of one Major Autohemotherapy.

Nowhere does she mention the number 95%.

And yet many websites refer to her when they claim those 95%.

Is it possible that she mentioned it in one of her other books? Possibly. But if so, it would have been strange if she said one thing in one book and something completely different in another.

But who knows?

Also: she doesn’t say what research the 1/3rd idea is based on. She only says it’s an “empirical formula”. But how was that formula created and by whom based on which observation? It’s not clear. So it may be that the real number is 5% or 10% or 50%. We don’t know.

Dr. Aubourg – the French Rectal Ozone Pioneer

Mrs. Renate Viebahn also refers to Dr. Aubourg when writing about rectal insufflations. Aubourg was a French physician who, as it seems, was one of the first who used rectal insufflations to treat patients. This was 1936. I found a text by Dr. Aubourg in yet another  book “Das medizinische Ozon” by Hans H. Wolff. But even there, there is no mention of the 95% figure nor a mention of how much RI compare to the intravenous method at all. I think if Dr. Aubourg had mentioned that RI were as powerful as ozone IVs, I'm sure that other ozone experts would have picked it up as something worth mentioning. And yet, there is nothing on the topic in Wolff's book. 

Prof. Velio Boccis' classic “Ozone – A New Medical Drug”

Renate Viebahn-Hänsler “Ozon-Sauerstoff-Therapie. Ein praktisches Handbuch”, translated: “Ozone-Oxygen Therapy. A practical Handbook”

Prof. Bocci and Rectal Insufflations

Then there is also Prof. Velio Bocci, one of the foremost ozone experts, or at least regarded as such by many contemporary ozone doctors. Prof. Bocci’s fame largely relies on his book “Ozone – A New Medical Drug” from 2005 which is considered by many as THE Ozone Bible par excellence.

There he writes:

“This […] would support the contention that the beneficial effect of RI in chronic limb ischaemia may be similar or equivalent to major AHT. If this result can be confirmed in a controlled, randomised clinical trial, it will be helpful for patients because they will be able to do automedication and avoid repeated venous punctures.”, p. 50, 51

So, what exactly does that mean?

He was essentially speculating that rectal insufflations COULD be similar or equivalent to intravenous ozone treatments. Nowhere was he claiming that this was an established fact. He was only proposing a theory.

He stresses a few times throughout the book that in order to find out if this theory was in fact correct, one would have to conduct randomized clinical trials.

“If, by an appropriate randomized clinical trial (RCT), we can prove that IR [sic] also has therapeutic activity in vascular disease, chronic hepatitis and intestinal diseases, we will have to promote RI, as the Cinderella of approaches, to the rank of AHT [Autohemotherapy].”, page 53.

Those, as far as I know, have never been performed. No randomized clinical trial exists which would compare RI with MAH (Major Autohemotherapy) in the treatment of any disease. 

And nowhere does he mention the number 95% when comparing rectal to intravenous ozone.

This should actually put the whole 95% myth to rest. But instead it appears that his speculations were misunderstood and picked up as if they were fact. And that’s although Prof. Bocci repeats several times in his book the importance of performing tests in order to verify his hypothesis. But this seems to have been totally ignored.

Consequently, a few years later in 2013, he co-authored a document entitled “The rectal insufflation is not the best administration route of ozone”.

Could the message be any clearer?

“The rectal insufflation is not the best administration route”

In that paper Prof. Bocci listed the following factors which he says make the effect of the rectal administration so uncertain:

1. The remainder of feces in the colon, and other compounds with which he says the ozone would invariably react and be neutralized.

2. During rectal insufflation it can come to involuntary releases of the gas, so it is uncertain how much of the original dosage remains in the colon and consequently how much ozone can be absorbed.

3. Ozone is never absorbed by the mucosa but instead “immediately reacts with the lining fluid”.

He concludes by saying:

“the dose of ozone acting as a really effective prodrug remains uncertain and variable, and the procedure remains empirical.”

Translated: We don’t know how much of the ozone is really used in a therapeutical fashion. Neither during a single administration, nor in general.

So, there is absolutely not a shred of evidence to support the belief that rectal ozone administrations could be anywhere near 95% as effective as intravenous ozone therapy.

This, plus an ozone generator and oxygen source, is all you need in order to perform RI. Some do with even less than that. Go to this page to learn how to do rectal insufflations

Should You Stop Doing RI?

But what does that mean for your situation? Should you stop putting ozone up your rear end?

First of all no, because we all need a little fun in our lives.

And second of all, you should not listen to a crazy ozone lady like me to find out what you should or should not do. This is something you should discuss with your doctor.

But does it mean that rectal insufflations are completely useless? No, absolutely not. There is actually reason to believe that they indeed do have a systemic treatment.

Best example is Brian. He’s been diagnosed with Multiple Sclerosis and he’s been treating himself with rectal insufflations and has seen tremendous progress. So much that he has even got an ozone tattoo on his body.

All I’m saying is that there is simply no evidence to support the claim of the 95%. And it doesn’t really matter, in my opinion. Even if the real effect is 30%, as Renate Viebahn alleges, or 10 or 20%, what matters is if it helps. And as long as it helps, keep doing it!

But also be aware of possible side effects.

Further Considerations – The Gold Effect

Having sufficiently debunked this idea of the 95% claim, I ask myself: how is it possible then that something without any evidence is so widely believed?

I think it has to do with a phenomenon, which often occurs in medicine, both alternative and conventional, and which is best described by the following:

It’s the combination of an idea which makes sense on paper, in this case the fact that medication can be in fact absorbed by the colon walls and then transported via the portal vein into the liver and then into the blood stream, see the way suppositories work, add to it observations which seem to prove a systemic effect, and as a final touch throw in the endorsement of ozone experts, and what you get is the so-called Gold-Effect in all its glory.

Paraphrased: “The Gold effect is the phenomenon in which an idea is developed to the status of an accepted position within a professional body through the social process itself like conferences, committees, and consensus building, despite not being supported by conclusive evidence.”

If you’re still not convinced, and if you still believe that RI are indeed as good as ozone IVs, you may want to consider the following:

General Questions

When looking at the statement “rectal insufflations are 95% as effective as the intravenous ozone” a few things should give you pause:

  • The generalization of this statement. There are hundreds of different conditions one can treat with ozone therapy. Some doctors treat the same condition with different ozone methods. Different patients respond differently to the same ozone approach. So even with the same condition it's impossible to say how effective the same ozone method is. So how could one make such a broad statement implying that rectal insufflations would be in general 95% as effective as ozone IVs? 
  • Which diseases does this pertain to? It's unlikely that all the possible conditions ozone is used for have undergone comparative studies which would allow for such a wide reaching statement. 
  • But most of all: how would one measure effectiveness? In medicine, when talking about effectiveness one talks about outcome, results. So symptoms disappearing, pain diminishing, skin conditions resolving, ability to function on a day to day basis improving, being able to go back to work. The above 95% statement implies that such improvements have been observed and documented in patients with the same conditions over and over again. When and where and by whom was such a gargantuan task ever performed? 
  • Some people may think that measuring the ozone byproducts in the blood after Ri and after ozone IV and comparing them is a good measure of effectiveness. That may be true, but one would also have to compare the change in ozone byproducts and the change in symptoms of a given disease. Is there a sufficient strong correlation? We know that ozone therapy induces changes in a whole range of blood markers, but whether that's what brings about healing or which one of those blood markers are responsible is not entirely clear yet. 

Let me know what you think. Have I overlooked some information which does prove that rectal insufflations are indeed 95% as effective as intravenous ozone? If so, let me know.

Thank you for reading and for commenting!


Renate Viebahn-Hänsler “Ozon-Sauerstoff-Therapie. Ein praktisches Handbuch”

Prof. Velio Bocci “Ozone – A New Medical Drug”

Hans H. Wolff “Das medizinische Ozon”

“The rectal insufflation is not the best administration route of ozone.”

“Rectal insufflations are a valid way in ozonetherapy”, Gregorio Martínez-Sánchez et al. 


About the author:

PaolaI’m Paola the Crazy Old Ozone Lady behind The Power of Ozone. I’m a licensed naturopathic practitioner, natural health consultant, ozone therapy enthusiast, researcher, and ozone therapy analyst. I hold certificates in ozone therapy, hyperbaric ozone applications, Oxyvenierung, and the Andrew Cutler chelation. I own several ozone generators including a German hyperbaric 10 Pass machine. I have been using ozone for over 13 years, I’ve chelated with the ACC program for close to 5 years and I’ve been carnivore for nearly 1.5 years. This website serves as a resource for those who are interested in ozone therapy and other approaches to successfully manage chronic conditions. 

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  1. Corbett

    In the town where I live in Tennessee, there are no doctors who would even THINK about using ozone in any way whatsoever. So it’s self-administered ozone or nothing. I believe that to be the case in much of the US. so while RI might not be the most effective way to administer ozone, it is that or nothing in much of the US.

    • Paola Dziwetzki

      Hi Corbett,

      there is drinking ozonated water,
      ozone saunas
      ozone body bags,
      Ear Insufflations

      Many people also do DIV at home.

      That's a lot of options besides RI.

    • Terry

      There are also no proven studies that state its not 95 percent as effective as mah so your article is mute..

    • Paola Dziwetzki

      HI Terry,

      There are also no proven studies that state that RI is not 200% as effective as MAH, so clearly it is, and anyone who says it's not, is mute.

      Trust the science.


  2. Barbara

    My husband had many, many MAH treatments. Now his veins have constricted and only has veins in his hands from which to draw blood. If he were to have a port so he could continue to receive ozone, would it continue to scar his veins further? Rectal insufflation is not strong enough
    Thank you for your reply

    • Paola Dziwetzki

      Hi Barbara,

      if the veins have scarred from MAH, then this is most likely from the continuous punctures, not so much from the drawing of the blood and re-infusion.

      I don't think that a port carries risk of scarring veins, but there are other risks like infections or embolisms (unrelated to what is injected).

      He may look into doing ozone saunas instead.


  3. Kerrilyn Chew

    Here is a study published in 2016 comparing MAH with rectal ozone on patients with metabolic syndrome:
    From the abstract: “Twenty-four individuals aged between 34 and 68 were recruited and included in the group treated with ozonated auto-hemoinfusion and other 24 individuals aged between 35 and 67 were recruited and included in the group treated with rectal insufflation of the oxygen-ozone gas mixture. According to the results obtained by means of oxygen-ozone mixture rectal insufflation, which are almost equivalent to the results obtained with the large ozonated auto-hemoinfusion, authors could conclude that the ozonated rectal insufflation can be taken into consideration as alternative method to the large auto-hemoinfusion, while treating the metabolic syndrome, in those patients difficult to manage due to the previously described reasons.”

    • Paola Dziwetzki

      Hi Kerrilyn,

      thank you very much.




  5. Carol

    We are using RI 2xday for prostate cancer at 20 mcg/ml and alternating with RSO suppositories for pain. We allow 30 minutes for the RI. Have you run across anything that might tell us if doing both is okay or is one cancelling out the other? Thank you.

    • Paola Dziwetzki

      Hi Carol,

      if with RSO you mean Rick Simpson Oil, I think that's a great idea, both alone or in combination with ozone.
      But I would up the ozone concentration to 40 to 60 mcg/ml. 20 mcg/ml is right on the verge of where the efficacy of ozone begins.


  6. craig jace

    you mentioned 3000mcg of rectal o3 instead of MAH
    what is 3000mcg in gamma and whats the quantity ml of one treatment?

    • paola d

      Hi craig jace,

      In order to know what concentration and volume to choose to get to 3,000 mcg, you calculate as follows:

      If you choose to use 200 ml of ozone/oxygen mix:

      3,000 mcg / 200 ml = 15 mcg/ml

      So, in order to get 3,000 mcg when using 200 ml of gas, you would need to choose an ozone concentration of 15 mcg/ml.

      Which in my opinion is very little.

      I would rather start with 20 mcg/ml and increase over time to around 40 mcg/ml.

      I hope this helps.


  7. Carlos López Rojo

    En mi experiencia, la mejor vía de administración de ozono es la Directa Intravenosa, no confundir con la autohemoterapia mayor. Llevo más de 2000 administraciones documentadas de la vía directa intravenosa y al compararla con otras vías, puedo concluir que ésta, es la que más rápido logra conseguir un cambio significativo en la salud del paciente al igual que en los exámenes de laboratorio, que puedan pasar 60 ml de gas oxígeno/ozono en 18 min a través de una vena, logra ozonizar más cantidad de sangre que la AHM y generar la cascada de reacciones bioquímicas necesarias para despertar esa vía final NRF2, potenciando el sistema antioxidante endógeno y todo lo que sabemos de la bioquímica del ozono. La vía rectal, logra resultados muy buenos, pero son más lentos y necesita de más sesiones. En Cuba se practica mucho, dado que es conveniente desde el punto de vista económico.
    Además, tal como lo explica el Dr. Bocci, el ozono es altamente reactivo, por lo que su reacción sería automática apenas encuentre moco intestinal o heces fecales, y la acción dependerá de los capilares existentes la mucosa del recto, pudiéndo generar ésta reacción en la sangre, al igual que en la vía sublingual.
    Por ésto, es que se necesitarían volúmenes Y tiempos de ozonización del paciente mayores.
    La AHM es una buena vía de administración, altera la naturaleza de la sangre ya que se administra anticoagulante, tiene un mayor costo dado los insumos. A nivel mundial es la vía más utilizada para terapia sistémica.
    Ahora, insisto en mis resultados de investigación clínica : la vía intravenosa directa es la mejor, más económica, depende de una aguja 30G 1/2′, o mariposa scalp, vía solucionada y jeringa, además de una bomba de infusión de jeringa para que el flujo sea constante yel volumen exacto. No tiene peligro alguno y el que diga lo contrario, que lo demuestre. Yo demostraré que es la mejor vía y segura.
    Los dejo invitados a Pontevedra, España, del 19 al 21 de junio Congreso AMOS , organizado por maestro Dr. Juan Carlos Pérez Olmedo.
    En éste congreso voy a exponer los resultados de mi investigación sobre la vía directa intravenosa y además mostraré como obtener distintos concentrados sanguíneos PRP, A- PRF e I- PRF que al ser ozonizados se pueden utilizar en medicina regenerativa.
    Dr. Carlos López Rojo.

  8. Christine

    Thank you for your research!

    • paola d

      Thank YOU for reading!

    • Mike

      Dr. Sylvia Menendez is a female Doctor. You can find her speaking ( rare) on YouTube.

  9. Dennis Harper DC

    I think you'd be wise to look at Doctor Sylvia Menendez work in Cuba. She has almost 30 years of research on using rectal ozone.

    • paola d

      Hi Dennis,
      I did look. But I could not find anything that would support the 95% claim. Unless you can point me towards something?


    • Robert

      My understanding is that Dr Menendez has generated many studies over decades that RI is effective in treating many medical issues. However, I have not seen any comparisons with other methods of Ozone treatments. I have heard Dr Rowen allude to the work of Dr Menendez as proof that RI is effective, but no direct comparison with other methods.

    • paola d

      Hi Robert,

      I'm aware of Dr. Menendez work on ozone therapy. Here he compiled an overview of studies about rectal insufflations:

      There is nowhere evidence that RI could be 95% as effective as MAH.
      The best he got is what I already posted above, namely the assertion that RI are around 33% of MAH. For which there is no evidence either. It's just a recommendation.


  10. Jeff S Arnold

    Very interesting article. And yes, we all need a little fun in our lives!
    In most treatments, what works well for one person may or may not work as well for the next, but we must keep searching for those treatments. Ozone, no matter which way of getting it into our body, is worth exploring and researching.

  11. Linda Schneider

    Robert Rowen, M.D. states in one of his interviews that he does RI on a daily basis. He reiterates their efficacy.


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