What Is Ozone Therapy?

by | Last updated: Apr 13, 2016 | 40 comments

Ozone therapy is the use of ozone/oxygen mix for curative purposes to either heal a condition or reduce its symptoms. One of the earliest mentions of ozone therapy dates back to 1885 when The Florida Medical Association published Dr. Charles J. Kenworthy's “Ozone”.

During ozone therapy, ozone is administered at different concentrations depending on which condition is treated and depending on the type of application. Ozone is very volatile, it can't be easily stored. It needs to be generated on site when used for ozone therapy (see also “How is ozone generated?“).

There are different ways to administer ozone:



Major Autohemotherapy (MAH): blood is extracted and mixed with ozone/oxygen outside of the body. An anti-coagulant like sodium citrate or heparin is added. The ozonated and heparinized mix is then reinfused into the patient.

GreenSmoothieGirl aka Robyn Openshaw is receiving a normobaric Major Autohemotherapy with additional UV light treatment.

Hyperbaric Major Autohemotherapy: 150 to 220 ml of blood are extracted and mixed with ozone/oxygen at a concentration of around 40 ug/ml outside of the body. An anti-coagulant like sodium citrate or heparin is added. The ozonated and heparinized blood mix is then re-infused into the patient under pressure of up to 0.9 bar. The high pressure protects red blood cells and allows for a better oxygen saturation.

1.5 ‘passes' of the Hyperbaric Major Autohemotherapy are performed using the Zotzmann Ozon 2000. This is the same machine which Dr. Lahodny uses for the Ozone High Dose treatments.

Ozone High Dose Therapy (OHT), also known as “10 Pass” method. It has been developed by Dr. Lahodny in Austria. It consists of extracting 200 ml of blood, mixing it with 200 ml of ozone/oxygen mix at a concentration of 70 mcg/ml and re-infusing it into the patient under high pressure. This is then repeated 10 times, hence the name 10 Pass. One 10 Pass application takes around 1 to 2 hours to complete, up to 20,000 units of heparin are used, 2 liters (2,000 ml) of blood are drawn and mixed with a same amount of ozone. A total of 140,000 ug of ozone is administered during a successful 10 Pass treatment.

The video shows one pass of the hyperbaric ozone treatments. During the Ozone High Dose 10 such passes are performed at a greater pressure and using higher ozone concentrations.

Ozonated saline IV: 0.9% saline solution is ozonated and infused into the patient intravenously. This is also called “the Russian Method” since it was first developed in Nizhnyi Novgorod, Russia. Low ozone concentrations of often less than 1 ug/ml are used. around 150 to 200 ml are continuously ozonated and infused into the patient.

A video I shot while receiving ozonated saline IV at a hospital in Nizhny Novgorod, Russia, where the method was invented.

Direct Ozone IV (DIV): the ozone/oxygen gas is introduced directly into the vein. Usually, 60 ml of ozone at maximum concentration of 55 ug/ml are injected. This needs to be done very slowly at around 1 ml per 30 to 60 seconds. Injections of up to 400 ml in one session have been reported without incidences. This procedure has been administered successfully on Ebola patients in Sierra Leone.

A patient of Dr. Jose Luis Gallardo receives a DIV at his practice in Queretaro, Mexico.

RHP / EBOO: RHP stands for Recirculatory Hemoperfusion, EBOO stands for Extracorporeal Blood Oxygenation and Ozonation. Both describe the same process: blood is extracted from one side of a person's arm, run through a type of dialysis machine where ozone is added, run through a filter, and then reinfused into the other arm. There are several clinics in Asia which offer this protocol, as do some clinics in the Ukraine.

EBOO (Extracorporeal Blood Ozonation and Oxygenation) performed on a patient at a clinic in the Ukraine. This type of RHP/EBOO also adds saline and uses a slightly lower ozone concentrations than what is used in Asia. The machine in the video is a unique invention of Prof. Eugeniy Nazarov. For a list of affordable EBOO / RHP treatment centers in Asia, please go here.


Injection of ozone gas into the joint. In the US this procedure has been made popular by Dr. Frank Shallenberger.

Dr. Bino Rucker injects ozone into the elbow and shoulder joints.


Injections of ozone into the muscle, either as pure gas or in the form of Minor Autohemotherapy: 2 to 5 ml of blood are drawn, mixed with ozone/oxygen mix and then reinjected into the muscle.

Minor Autohemotherapy: a mixture of the patient's blood and ozone is injected into the muscle.


Used to relieve pain or for cosmetic purposes



Into wrinkles to stimulate collagen production


  • injection into a tumor for tumor dissolution


  • intraarterial injection



Introduction of ozone/oxygen gas into various body cavities:

– ear insufflations

– vaginal insufflations

– rectal insufflations

– bladder insufflations

– nasal insufflations

– Intraperitoneal insufflations

An incision is made and ozone is introduced into the peritoneum (a membrane which lines the abdominal cavity). This procedure can only be performed at a clinic.

  • ozone cupping with a funnel. It can be also be performed using a vacuum cup which is ‘sucked' onto the skin.


  • limb bagging: this is performed to treat wounds or gangrene.



  • ozonated water enema



Water has the ability to bind ozone for a limited time. Ozonated water can be ingested to treat gastrointestinal conditions or to rinse nasal cavities or wounds. It can also be used in surgery to speed up healing and prevent infections.


Ozone is added to a sauna which allows for the person's head to remain outside.

I demonstrate how to set up an ozone sauna at home.
A special type of sauna is the HOCATT ozone sauna: it adds carbonic acid which is supposed to enhance the body's ability to absorb oxygen, hence making the ozone sauna more effective.
Dr. Tonya Bastress presents the HOCATT ozone sauna.

  • ozonated oil: it can be ingested, used as a suppository, or topically to treat inflammation or to promote wound healing.


  • dental use of ozone: to prevent root canals and caries


Continue with “How to protect yourself from breathing ozone?


  1. Isadora Guggenheim

    Yes Covid caused cytokine storm, elevated D-Dimer, ferritin, Anti-cardiolipin AB IGM, Beta Cardiolipin IGM, Interleukin 6, 8, 13, 17, Interferon Gamma, MMP9, CRP protein and CRP Systemic, RBC, Hemoglobin, Hematocrit, RDW, Hepcidin, Heinz bodies, Histamine, Trypsin and more. I.V. Ozone was very effective at reducing these markers, addressing hypercoagulability and stopping cytokine storm. It is a short pro-oxidant that stimulates/activates all anti-oxidant pathways in all cells. Stimulated Nrf2 as part of our survival gene. Very effective for Covid and other viruses including HSV 1 and 2, Hep C and HIV. Patients recovered very quickly and pulse oximetry that was 81 and falling came up to 96 in one session. This prevented hospitalization and ventilation. Ozone saved lives as evidenced in the book Ozone for Life.

  2. Sally

    Hi Paola-

    Thank you for all this great information. I have struggled with bad rosacea and cystic acne for almost a decade. This past fall, I discovered ozonated oil and my face has improved by 90% over 3 months. Because of this amazing success, I have become interested in ozone internally (as I have always suspected my skin condition is virus-related since it seemed to start when I got Epstein-Barr) to help get rid of the uncomfortable awful flushing episodes. I got MAH done for the first time recently and I definitely saw improvement but it is just too expensive to get again and again. What would you suggest is the next best way to get ozone into the bloodstream to treat a chronic virus-related skin condition? Thank you very much!

  3. Kevin San Juan

    I have a cheap water ozonation device. I'm confused as to why an oxygen tank is necessary. Are there drawbacks to using a cheap device that uses surrounding air to produce ozone?

    • Paola Dziwetzki

      Hi Kevin,

      air-fed ozone generators are fine to ozonate water, vegetables, or for cleaning purposes.

      For therapeutical purposes, in general oxygen-fed generators are used, where the concentration and amount of ozone can be finely controlled.

      The air fed generators can also create HNO3, nitric acid, a very corrosive molecule. Especially if the generators do not have an air dryer.



  4. James Awad

    IS ozonated Water and Ozone treatments Help Reduce Nephrolest Sinderome ?.

  5. Raphael

    Hi Paola,

    Thank you for this excellent post and for all the knowledge about Ozone and health in general. I'm learning a lot!

    My mother was suffering very often with cystitis. Then I started to give to her Ozonated Water – one day ON and one day OFF. And it helped her for many months – without it, she had cystitis every 2 or 3 months.

    But now, even drinking ozonated water she has had cystitis.

    So, I found a youtube video where a lady explains how she does urethral insufflation – I guess that urethral insufflation may be way stronger than ozonated water because the ozone has direct contact/access to the urethra and the bladder. Ozonated water needs to pass to the esophagus, stomach, kidneys, etc. until it arrives in the bladder.

    Please, if possible to know your learned opinion, what do you think of this method of urethral insufflation: https://www.youtube.com/watch?v=3GAcGG7H8zw

    ** I know that it would be more correct to go to the doctor. But unfortunately, the doctors in my city only do rectal insufflation, major autohemotherapy, minor autohemotherapy, and ear insufflation.

    Thank you so much!

    All the Best!

  6. John

    Can any form of ozone kill good gut flora bacteria the same way it kills pathogens?

    • Paola Dziwetzki

      Hi John,

      only rectal insufflations are likely to accomplish this. Whether they can kill enough bacteria to be of clinical significance or if it has no negative impact on the health of the patient is not clear.


  7. Dave

    I've never done ozone before. I only have enough money to do either DIV or MAT. I think its safer to experiment with DIV first but I will get more bang for my buck if I do the MAT. Do you think I'm okay just going straight to MAT for my first time? And I will bring Vitamin C supplement with me just in case the practioner doesn't have it. Do you know what dose would be sufficient to cancel out effects if something goes wrong?

    • Paola Dziwetzki

      Hi Dave,
      what protocol will bring you most bang for your buck depends on what you're treating.

      Yes, you should be ok with doing MAH, it's a gentle treatment with relatively few adverse effects.

      MAH usually does not create ozone overdoses. In case it does, dissolve a few grams (2 to 5g) of Vit C in water and drink it.

      Better are Vitamin C IVs. But it's really unlikely that this will be necessary with MAH.


  8. mug

    Hello, Paola:

    Thanks for great information! I have very high dimer: 580 D-DU_ng/mL . Standard Range is 0 – 230 D-DU_ng/mL

    I wonder if there will be clog issue when doing ozone if the dimer is very high?

    Many Thanks!

    • Paola Dziwetzki

      Hi mug,

      I don't know.

      What type of ozone treatments did you have in mind?


  9. Peter

    Hi Paola,

    Do you know if ozone treatment can help to cure MND (motor neuron disease) or is that impossible.

    • paola d

      Hi Peter,
      I don't recall anyone saying that they cured MND with ozone, which doesn't mean there aren't such cases, I don't know.
      I think it depends on what the cause is. If it's due to inflammation or an infection, ozone may help.
      If it's due to metal toxicity, I suggest Andrew Cutler Chelation.
      If it's due to structural problems, I suggest seeing a neurosurgeon or chiropractor.


  10. Cilla

    Hi Paola

    Can ozone penetrate the mucous/slime that surrounds a tumour? My understanding is that the tumour creates mucous to protect itself (to the extent that many chemo drugs can't get through it), but can the ozone get through to attack the tumour? I have a tumour that started in the colon but has grown through to the uterus, so I am doing RI and VI, and am hoping that some ozone can get through the slime to the tumour in both places!

    • paola d

      Hi Cilla,

      I didn't know tumors were surrounded by mucous …
      What I do know is that there is a whole number of ozone doctors who claim to see results in cancer patients when treating them with ozone.
      There is one video on Youtube of Dr. Frank Shallenberger where he says that when the tumor is directly exposed to the ozone that that's when one sees the best outcomes. For example in intestinal tumors who are treated with rectal insufflations, since the tumor is directly exposed to the gas.


    • Cilla

      Thank you Paola – I just have to hope that the ozone can get through the mucous.

      Do you know the name of the video? There are pages of them on YouTube all featuring Dr Frank Shallenberger.

  11. Rob

    This site recommends the Cutler Protocol as well as ozone. Andy Cutler always warned mercury toxic people not to do therapies such as hyperbaric oxygen because they are oxidative catalysts that cause additional oxidative stress. Can you please explain to us what makes ozone ok for merucry poisoned people when hyperbaric is not? Thank you.

    • paola d

      Hi Rob,
      I don't think this is correct: “Andy Cutler always warned mercury toxic people not to do therapies such as hyperbaric oxygen because they are oxidative catalysts that cause additional oxidative stress”.
      Andy warned against hyperbaric oxygen therapy especially for autistic kids since he saw many of them get worse. I don't think he ever blamed oxidative stress caused by HBOT for that. I don't think he ever gave an explanation for why they would regress, it was just an observation he made. Given that during HBOT therapy there are 2 things going on: the pressure AND the breathing of oxygen, one can't actually say that it is the oxygen part which causes the problems, and Andy never specified that. It is entirely possible that it is just the pressure part itself.

      Some people who are experts on HBOT actually pointed out that there are different ways to perform HBOT: with 100% pure oxygen (which is much more expensive and the preferred “real” HBOT) or with lower concentrations of oxygen. They said that the adverse reactions occur predominantly during the HBOTs which try to cut corners with the oxygen. I personally don't know. I have never investigated that issue in such a depth. And neither has Andy as it seems.

      “Can you please explain to us what makes ozone ok for merucry poisoned people when hyperbaric is not?” – Because many mercury toxic people benefit greatly from ozone therapy, yours truly included.

      Andy was asked about ozone therapy a number of times, also in the group “Andy Cutler chelation support group” on Facebook where you should be able to still find his quotes. He said that ozone therapy during chelation and in general was fine.

      During personal conversations with me, it became clear that he was well aware that ozone does not increase oxidation in the body, it actually stimulates antioxidant activity. So it fights oxidative stress.

      Hope this clears it up.

  12. Dominic

    Hi Paula,
    could I also get the details on the place doing Major Autohemotherapy in London ?


    • paola d

      Hi Dominic,
      I sent you an email a few days ago.
      Did you get it?

    • mcg

      I have been getting 10 pass at the Hale clinic in London. Dr. Katrin Hempel, B.H. Sc., ND, Dipl.Ac.
      Naturopathic Doctor, Herbalist, Nutritionist, Homeopath, Acupuncturist

    • paola d

      Cool. How much do you pay?

    • ilona

      Eoin, would you share where you went? I'd love to hear where in Berlin you went, and how you liked it there….thanks!

  13. Eoin

    Hi Paola, Do you know anyone who is doing Major Autohemotherapy in the UK or Ireland or would Germany be the closest place to there where someone is working with this therapy? Cheers

    • paola d

      Hi Eoin,
      yes, I do know someone in London who does MAH.
      Can I email you the name and address?

    • Eoin

      Thanks Paola. I just saw this now. I found a place in Berlin so went there but I think I'd like to try EBOO RHP next for a circulation issue I have. Cheers 🙂

  14. mark olinyk

    The many great uses of ozone. What an awesome wonderful treatment. Thanks or posting.

  15. neil shuell

    hi can u please give places to recieve high ozone usa and otherwise

    • paola d

      Hi Neil,
      please join the Facebook group “Ozone to Health” to look at the list.

  16. Greg

    This is really good. It shows all the various types of ozone therapies and applications.

    • paola d

      Thank you!

    • rodney gangapersad

      great information.With regards to the IV ozone/oxygen mixture, what happens to the nitrogen in the gas mixture when introduced intravenously ?

    • Paola Dziwetzki

      Hi rodney,

      there should never be any nitrogen during any type of ozone IV.



      Dear Dziwetzki

      Your site is the best site i have seen. Well done!

      I need your help, i am supporting and research Ozone for use to dirupt the sar2 corona vius and Covid19 disease.

      I believe iHave had it, do to my poor immune system and used a combination of protocol mis matched ill advise attemp not to get into the cytokind storm.
      What ever I did it worked. Some of what I have learned over the last 3 years and treating my sisters cancer .worked.. but I am not a practioner. Just a strategist.
      See one of my group is the Palestinian Authority, in Ramallah.

      I need a partner, a solution ..

      Pleae look at Ozonewithout borders.ngo, tell me what you see.
      Its the DIV ozone , by Dr.Rowan. to my understanding iltgats all there is.

      Other the the high donation, why do I feel uncomfortable.

      Your option is of great importance to me, and greatly needed.

      I am trying to fight the corona virus by openning up the Ozone Practioners opportunities. (THE WORLD IS)

      What can I do?

      So you know I flew to Ramallah and met the PA (I am a peace Strategist)and they introduced me to Dr Najjar head of Palestinian Medical Research and his staff.

      I look forward to you email reply,

      MY CELL NUMBER is 604 6490385.
      Ozone Health Solutions Research

    • rodney gangapersad

      Do you leave the ozone generator on while in the steam sauna

    • Paola Dziwetzki

      Yes, of course!


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