What to Expect After Your First Ozone IV?

by | Last updated: Mar 22, 2022 | 6 comments

What to expect after your first ozone IV

You scheduled your first ozone IV and now you are waiting.  

You spend the time researching ozone therapy and come across the usual misinformation sources, spreading Big Pharma sponsored confusion. 

The intentionally overblown horror stories don’t seem to offer a realistic picture of what to expect.

Websites of ozone therapy doctors on the other hand only talk about rainbows and unicorns: “No side effects, only improvement! Call our office today and book your ozone treatment!” 

So, what is gonna happen? 

Will you die? Will you herx? Will you become superhuman? All of those things? 

Possible. But improbable. 

Here is what is most likely to occur after your first ozone IV.

Different types of ozone IVs cause different reactions 

Before researching what will happen after your first ozone IV, you should become aware that there are the different types of intravenous ozone administration.

There is more than one and depending on what type of ozone IV you will receive, you may experience different reactions.

The following are all ozone IVs: 

The first five require an anti-coagulant. In most cases that’s heparin.

During those treatments blood is drawn and mixed with ozone outside of the patient’s body. 

To prevent clotting during that time, heparin is added. Sometimes, instead of heparin, sodium citrate is used. 

Heparin is a usually well tolerated drug, but it comes with a long list of side effects. Most of those are benign and transient. It’s a good idea to acquaint yourself with them, so you know what to expect. 

Common symptoms are shortness of breath, joint pain, abdominal swelling, chills, fever, itchiness, brown urine or headaches. But there are more.

This means that any ozone IV that is performed with heparin can trigger any of those symptoms. 

The other two types of ozone IVs (DIV, O3 saline IV) do not call for an anti-coagulant.

Ozonated saline IV can lead to phlebitis if the ozone concentration is too high.

The same is also common with DIV, direct intravenous ozone injections.

Here, pure ozone/oxygen gas mix is introduced into the vein. Typical side effects are inflammation of the vein and also chest tightness. This is likely due to micro-embolisms in the lungs and passes within 20 to 30 minutes. It is important to know how to handle this type of situation correctly. 

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How long does it take to feel an improvement after an ozone IV? 

This depends on what is being treated. Oftentimes, the condition dictates the reaction.

A general rule of thumb is that if there is an acute infection or inflammation present, the more likely is an immediate, significant and positive response.

With a chronic condition, the improvement tends to be more subtle and there is a higher risk of a Herxheimer reaction.

Whether with an acute or chronic condition, it is not uncommon to see an immediate improvement in symptoms.

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Often it is characterized by an increase in energy, lessening of pain, reduction in fatigue. Some also report a clarity of mind and a lifted mood. 

Some symptoms may resolve already during the IV. It is not unusual for patients to see their symptoms resolve before they get up from the treatment chair.

Of course, there are many exceptions.

Some conditions may not respond to ozone IVs at all. 

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As with everything, ozone therapy does not work every time, for everyone and equally well. 

The initial improvement may be also just temporary and symptoms may re-appear later. This is a often taken as a sign to repeat the treatment. 

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Do ozone IVs cause Herxheimer reactions?

Yes, intravenous ozone treatments can trigger Herxes, although this is quite rare, according to some ozone doctors. 

Dr. David Brownstein says in his book “Ozone: The Miracle Therapy” that they happen only in around 5% of the cases, although he does not specify for which ozone treatments this holds true. 

According to my observations, I would agree that ozone IVs trigger Herxes less often than non-invasive treatments like ozone saunas or ear insufflations. 

Herxes are not necessarily something to be afraid of. They are often taken as a sign that the therapy is working and that it should be continued. Ozone therapy is a natural, holistic approach that does not cause lasting damage, unlike pharmaceutical interventions. 

Dr. Brownstein recounts a case of Herxheimer reaction in the treatment of fibromyalgia with MAH, Major Autohemotherapy. 

Miranda suffered from full body aches and fatigue. She received 120 ml of ozone at an ozone concentration of 70 mcg/ml. 

Here is what she reported:

I felt like I had the flu. I was achy and fatigued but differently from my fibromyalgia symptoms. I called you and you thought this was a Herxheimer reaction and that I should take it easy until the symptoms passed. All the symptoms gradually went away in a week, and I felt much better. I mean, my fibromyalgia symptoms were nearly gone. I couldn't believe it, as I have not been pain-free for many years. After the second ozone IV, I became achy and fatigued like after the first one, but this time it only lasted for a few days. Again, when I came out of it, I felt almost 100% pain-free. At this point, I knew it was working. I had a third ozone IV and felt the same achiness for only a day, then no pain. I could cry because I feel so much better. now, I am doing ozone at home rectally and i continue fo feel great. This has totally changed my life.”

Achiness, feeling like having the flu, elevated body temperature, sensations of chills, joint pain, runny nose — those are some of the typical, ozone induced Herheimer reactions.

My Herxheimer experience after ozonated saline IV

One of the most dramatic Herxheimer reactions I encountered was after my first ozonated saline IV. It was after I left Dr. Chandler Clark’s office in upstate New York. 

On my way back home, I felt cold and my body started feeling like it was made of ice crystals. I felt stiff, sweaty and had chills — all at the same time. Later, in the subway, I thought I would pass out. People started looking at me. In the end, I didn’t lose consciousness, but I felt like it was a close call. I had never experienced anything like it before in my life. 

Back home, I was elated: I took all of this as a sign that the therapy was working and later went back for more. 

This was more than 12 years ago and the rest is history … 

More testimonials

Some additional testimonials of what patients experienced after ozone IVs. Taken from The Ozone Group

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About the author:

PaolaI’m Paola the Crazy Old Ozone Lady behind The Power of Ozone. I’m a licensed naturopathic practitioner, natural health consultant, ozone therapy enthusiast, researcher, and ozone therapy analyst. I hold certificates in ozone therapy, hyperbaric ozone applications, Oxyvenierung, and the Andrew Cutler chelation. I own several ozone generators including a German hyperbaric 10 Pass machine. I have been using ozone for over 13 years, I’ve chelated with the ACC program for close to 5 years and I’ve been carnivore for nearly 1.5 years. This website serves as a resource for those who are interested in ozone therapy and other approaches to successfully manage chronic conditions.

Legal Disclaimer

Information provided is for informational purposes only and is not a substitute for professional medical advice. No health claims for these products or treatments have been evaluated by the United States Food and Drug Administration (FDA), nor has the FDA nor any other medical authority approved these treatments or products to diagnose, cure, or prevent disease. Neither The Power of Ozone nor the manufacturers of these items are responsible for the misuse of this equipment or the information on this page. It is highly advised to receive professional council from a licensed doctor before using ozone therapy or any of the mentioned products or tests on yourself.

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This website contains links to vendors of products I endorse, including amazon.com. If you decide to make a purchase through one of my links, they will pay me a commission. This does not influence my opinion about the products, as you can see from my reviews.


  1. Heidi

    I have had chronic Lyme for 15 years and have done multiple protocols to try and get relief. Some helped, some didn’t. I recently tried EBOO. It has been 5 days and I am having kidney pressure and slight pain. Why do you think that is? The EBOO is supposed to take out the toxins, so why is my kidney struggling?


    Paola, I am a 72-year-old retired nurse of 30+ years. I have Chronic Pain, Fibromyalgia, and Gut problems. After years of doctors and narcotics, my symptoms have not improved. I went off of the narcotics and after some research, found out about Ozone Therapy. I have lost faith in medical practitioners. I am not alone. Do you think Ozone IV Therapy will help me even at my age? (I love your name)

    • Paola Dziwetzki

      Hi Linda,

      thank you for contacting me. I think there is the possibility that ozone IV therapy would help with your problems, yes. Some ozone practitioners report success with fibromyalgia.

      Also looking into reducing your vitamin A intake, or checking your supplements for vitamin A and eliminating them, this could also help and/or improve your outcomes with ozone.

      If you decide to go for ozone IVs, I would probably look into DIV, MAH (Major Autohemotherapy), or ozonated saline IVs first, and from there on scale up to multi-passes or 10 pass.


  3. Mike

    Paola — I have had many different types of ozone treatment over the last 18 months: sauna, MAH, high-dose UBI (UV), and lots of insufflations, ozone water. They are gradually healing damaged nerve tissue, caused by 2 autoimmune events many years ago (transverse myelitis). I tolerated all of the treatments very well. In March, I had 1 DIV treatment (20 cc @ 30 gamma concentration). It resulted in a severe case of oxidative stress which has left me with vertigo. I know that it was oxidative stress, because the reaction was comparable to cases of exercise-induced oxidative stress, which I have experienced when I pushed too hard too fast in the past. The only difference: the after-effects are not going away. Herx is not the only potential side effect of ozone IV. Now I am looking for ways to reverse the vertigo (high-dose oral Vitamin C, hydrogen-rich water).

    • Paola Dziwetzki

      Hi Mike,

      sorry for your bad experience! Vertigo is the worst. I have been dealing with it on and off for the past few years. The last worst episode was triggered by vitamin B1.

      Let me know if you have any questions and I wish you a speedy recovery.


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